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Peyronie's disease (PD) or Induratio Penis Plastica (IPP) is a chronic inflammation of the albuginea tunica of the corpora cavernosa which causes an inelastic plaque with consequent deformation of the penis.
In recent years, numerous studies have demonstrated the role played by oxidative stress in the pathogenesis of La Peyronie's disease, and other studies have described the success of the use of antioxidants in the treatment of P.D.
Therefore the combined therapy represents an effective treatment strategy, capable of treating La Peyonie disease at an early stage, achieving better results than those traditionally obtained with a single substance.
Review Article Recent Pathophysiological Aspects of Peyronie’s Disease:
Currently the most appropriate treatment strategy is therapy that includes antioxidants associated with antifibrotic drugs.
Paulis et al. " Pentoxifylline Associated with Other Antioxidants (Multimodal Therapy) on Patients with Peyronie's Disease. Results of a Controlled Study" Andrology 2014 3:2
The latest, very encouraging studies indicate Pentoxifylline in association with vitamin E and other antioxidant substances such as Propolis, Blueberry, Silymarin, Ginkgo Biloba, Coenzyme Q10; as substances capable of significantly reducing the volume of plaque and bowing.